Gut Health

The gut is where metabolism, mood & immunity meet.

When your digestive tract works well, the rest of the body follows. When it doesn't, the effects show up well beyond your stomach: in your weight, blood sugar, energy, skin and mood.

GUTTHE CENTERWeightMetabolicMoodImmunityInflammation
Gut → Weight

Appetite & fullness

Gut hormones such as GLP-1 and PYY tell your brain you are full. Your microbes also influence how many calories you extract from food.

  • GLP-1 and PYY signal fullness
  • Microbes affect energy harvest
  • Fiber feeds bacteria that support satiety
Clinical briefs

The three gut problems I see most, and what actually helps.

01

Acid reflux, GERD & erosive esophagitis

Heartburn, regurgitation, chronic cough or hoarseness
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By Kevin S. Palumbo, MD

Reflux happens when the valve between the esophagus and stomach relaxes when it shouldn't, and acid washes upward. An occasional episode after a large meal is normal. Heartburn twice a week or more is GERD, and it deserves a real plan.

What drives it

  • Extra weight around the abdomen, which pushes stomach contents up
  • Late, large meals and lying down soon after
  • Alcohol, nicotine, and for some people coffee, chocolate, mint or spicy food
  • A hiatal hernia

What helps

  • Finish eating three hours before bed and raise the head of the bed
  • Modest weight loss: even 5–10% of body weight often reduces symptoms
  • Acid-suppressing medicine, chosen and reviewed with your doctor instead of taken indefinitely on your own

Erosive esophagitis and healing

When reflux goes on long enough, stomach acid can wear sores, called erosions, into the lining of the esophagus. This is erosive esophagitis. It is diagnosed with an upper endoscopy and graded from A (mild) to D (severe). Healing means the erosions have closed on a follow-up exam. Treatment then shifts to keeping the lining healed so the damage doesn't come back.

Today's medicines, and what's new

Proton pump inhibitors (PPIs) have been the standard acid-suppressing treatment for decades and work well for many people. Some patients, though, keep having breakthrough heartburn or erosions that don't fully heal on standard therapy.

Newer option · PCABs

Potassium-competitive acid blockers (PCABs) are a newer class of medicine, FDA-approved in the US to heal erosive esophagitis, keep it healed, and relieve heartburn. They shut down the stomach's acid pump in a different way than PPIs. They compete with potassium at the pump, don't need stomach acid to activate them, and can be taken with or without food.

Still struggling with reflux despite treatment? Ask your GI doctor whether a PCAB is right for you.

Long-standing reflux can also change the lining of the esophagus (Barrett's esophagus). If you've had symptoms for years, an upper endoscopy is a reasonable conversation to have.

02

Irritable bowel syndrome (IBS)

Cramping, diarrhea, constipation, or both
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By Kevin S. Palumbo, MD

IBS affects roughly 1 in 10 adults. It is a real disorder of how the gut and brain communicate. The gut becomes more sensitive and its movement less coordinated, even though scopes and scans often look normal.

What drives it

  • Stress and poor sleep, through the gut–brain axis
  • Certain fermentable carbohydrates (FODMAPs) in foods like onion, garlic, wheat and some fruits
  • A previous gut infection, which can set off IBS afterward

What helps

  • A structured low-FODMAP trial with planned reintroduction, ideally with a dietitian
  • Soluble fiber such as psyllium, increased slowly
  • Regular exercise, consistent meals and stress work such as gut-directed hypnotherapy or CBT
  • Medicines matched to your type of IBS when lifestyle changes are not enough
03

Bloating & constipation

Pressure, gas, infrequent or hard stools
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By Kevin S. Palumbo, MD

Bloating is one of the most common reasons people search for gut help. Often the cause is simple: stool and gas that move too slowly. Less often it is small intestinal bacterial overgrowth (SIBO), food intolerances or a pelvic floor problem.

What drives it

  • Low fiber and low fluid intake
  • Sitting most of the day
  • Medications, including some used for weight loss such as GLP-1 drugs
  • Ignoring the urge to go

What helps

  • Build up to 25–30 g of fiber a day from plants, plus plenty of water
  • A daily walk after meals to stimulate gut movement
  • A footstool to improve position on the toilet
  • Testing for SIBO, celiac or thyroid problems when bloating persists

If you're on a GLP-1 medication, tell your care team about constipation early. It is common and very manageable.

Educational content only. These briefs are not a diagnosis or a substitute for an exam. Medicine content is general and disease-state only.